BDBM50306269 5-oxo-5-(7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1,7]naphthyridin-1-yl)pentanoic acid::CHEMBL595681

SMILES OC(=O)CCCC(=O)N1CCc2cccc3C(=O)NCC1c23

InChI Key InChIKey=CFOCNCPFSCAEMG-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306269   

TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306269(5-oxo-5-(7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de]...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306269(5-oxo-5-(7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed