BDBM50306249 1-(2-(4-(benzyloxy)phenyl)acetyl)-2,3,9,9a-tetrahydro-1H-benzo[de][1,7]naphthyridin-7(8H)-one::CHEMBL594522

SMILES O=C(Cc1ccc(OCc2ccccc2)cc1)N1CCc2cccc3C(=O)NCC1c23

InChI Key InChIKey=RBPSUSGZEBUPLW-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306249   

TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306249(1-(2-(4-(benzyloxy)phenyl)acetyl)-2,3,9,9a-tetrahy...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306249(1-(2-(4-(benzyloxy)phenyl)acetyl)-2,3,9,9a-tetrahy...)
Affinity DataEC50:  580nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed