BDBM50306162 (S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)pyridin-2-amine::CHEMBL593573

SMILES CCNc1nc(-c2ccoc2)c(cc1OC[C@@H](N)Cc1ccccc1)-c1cnc2[nH]nc(C)c2n1

InChI Key InChIKey=CEKSBBZAKLNEBU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50306162   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306162((S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306162((S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306162((S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306162((S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK2beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306162((S)-3-(2-amino-3-phenylpropoxy)-N-ethyl-6-(furan-3...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed