BDBM50306158 3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-methyl-1H-pyrazolo[3,4-c]pyridin-5-yl)-6-(2-methylfuran-3-yl)pyridin-2-amine::CHEMBL595459

SMILES Cc1n[nH]c2cnc(cc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c(N)nc1-c1ccoc1C

InChI Key InChIKey=AQJWACKPYCXBCF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50306158   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCasein kinase I isoform epsilon(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 680nMAssay Description:Inhibition of GSK2beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 1.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306158BDBM50306158(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50: 3.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed