BDBM50306121 6-(8-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide::CHEMBL595231

SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(O)c1cccc(F)c1O2)c1ccccc1

InChI Key InChIKey=DBALZNPBWHMHOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306121   

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306121(6-(8-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine...)
Affinity DataIC50: 33nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306121(6-(8-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine...)
Affinity DataIC50: 315nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed