BDBM50306117 CHEMBL593352::N-(2-hydroxy-2-phenylethyl)-6-(spiro[isochroman-3,4'-piperidine]-1'-yl)pyridazine-3-carboxamide

SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)Cc1ccccc1CO2)c1ccccc1

InChI Key InChIKey=BCQSGWNKFDAIOL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306117   

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306117(N-(2-hydroxy-2-phenylethyl)-6-(spiro[isochroman-3,...)
Affinity DataIC50: 76nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306117(N-(2-hydroxy-2-phenylethyl)-6-(spiro[isochroman-3,...)
Affinity DataIC50: 400nMAssay Description:Inhibition of SCD1 in human liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins at 0.4 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed