BDBM50306113 CHEMBL594083::N-(2-hydroxy-2-phenylethyl)-6-(4-methoxyspiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide

SMILES COC1CC2(CCN(CC2)c2ccc(nn2)C(=O)NCC(O)c2ccccc2)Oc2ccccc12

InChI Key InChIKey=RJTHOZRLXMDNHA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306113   

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306113(N-(2-hydroxy-2-phenylethyl)-6-(4-methoxyspiro[chro...)
Affinity DataIC50: 60nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306113(N-(2-hydroxy-2-phenylethyl)-6-(4-methoxyspiro[chro...)
Affinity DataIC50: 600nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed