BDBM50305810 1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dione::CHEMBL595838

SMILES NS(=O)(=O)c1ccc(cc1)C1=C(C(=O)NC1=O)c1ccccc1

InChI Key InChIKey=LCBYKMOZFZMSHI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50305810   

TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50305810(1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dion...)
Affinity DataIC50: 610nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50305810(1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dion...)
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50305810(1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dion...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50305810(1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dion...)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of COX2 assessed as PGF2alpha level by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed