BDBM50305533 (S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-19-methyl-11,16-dioxa-3,18-diaza-tricyclo[15.3.1.1*6,10*]docosa-1(21),6(22),7,9,17,19-hexaen-2-one::CHEMBL589369

SMILES CC(C)c1cccc(CNC[C@@H](O)[C@@H]2Cc3cccc(OCCCCOc4cc(cc(C)n4)C(=O)N2)c3)c1

InChI Key InChIKey=TVDHOONBSNHWKJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50305533   

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50: 55nMAssay Description:Inhibition of BACE1 expressed in APP-overexpressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50: 156nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin E(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50: 8nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed