BDBM50305146 4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl)-1H-pyrrole-3-carboxamide::CHEMBL589630

SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F

InChI Key InChIKey=HNWZKSBXLQWJOE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50305146   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 23nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed