BDBM50305056 (R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin-3-yl)(2-ethylpiperidin-1-yl)methanone::CHEMBL593590

SMILES CC[C@@H]1CCCCN1C(=O)c1cnc(Nc2ccc(C)nc2)c(Cl)c1

InChI Key InChIKey=QABUURICQJOWID-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50305056   

TargetMetabotropic glutamate receptor 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305056((R)-(5-chloro-6-(6-methylpyridin-3-ylamino)pyridin...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]ABP688 from human recombinant mGluR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed