BDBM50305006 5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine::CHEMBL590109

SMILES NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc12

InChI Key InChIKey=JPOSFPUHBHRUAX-UHFFFAOYSA-N

Data  75 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 50305006   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERBB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERBB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of BLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDeath-associated protein kinase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of ZIPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetInsulin receptor-related protein(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHigh affinity immunoglobulin gamma Fc receptor I(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGFR1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 510nMAssay Description:Inhibition of PAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 440nMAssay Description:Inhibition of DYRK1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 400nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 380nMAssay Description:Inhibition of PLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 170nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 53nMAssay Description:Inhibition of pdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 19nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 530nMAssay Description:Inhibition of Ck1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 230nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
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