BDBM50304937 CHEMBL591796::N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide

SMILES FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nn1)C(=O)NCCc1ccccc1

InChI Key InChIKey=TVSDBYTZFAQONZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50304937   

TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304937(N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piper...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304937(N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piper...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Scd1 in human HEK293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304937(N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piper...)
Affinity DataIC50: 18nMAssay Description:Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304937(N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piper...)
Affinity DataIC50: 18nMAssay Description:Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50304937(N-phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piper...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed