BDBM50304527 CHEMBL492677::N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

SMILES CN1CCN(CC1)c1cc(NCc2ccccc2)nc(N)n1

InChI Key InChIKey=GXRZHULPUGZJMQ-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304527   

TargetHistamine H4 receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50304527(N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at histamine H4 receptor (unknown origin) expressed in HEK293T cells harboring CRE-luciferase after 6 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50304527(N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at histamine H4 receptor (unknown origin) expressed in human U2OS cells increase in beta-arrestin2 recruitment after 2 hrs by lumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50304527(N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50304527(N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4...)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed