BDBM50304371 CHEMBL611216::N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(2-(2-methoxyethoxy)ethoxy)acetamide::US9320734, 103

SMILES COCCOCCOCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1

InChI Key InChIKey=FOURIWOYGUHXMN-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50304371   

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304371(N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(...)
Affinity DataKd:  2.04E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304371(N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50304371(N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Akt phosphorylation in human BxPC3 cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50304371(N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(...)
Affinity DataKi:  4.10E+4nMAssay Description:Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50304371(N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)-2-(...)
Affinity DataKi: >5.00E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent