BDBM50304208 CHEMBL595406::N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(cc3C)-c3nc4ccccc4s3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=SSHDKAJDJAVHAF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50304208   

TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 38nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 250nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 250nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 340nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 340nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 440nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 490nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304208(N-(4-(benzo[d]thiazol-2-yl)-2-methylphenyl)-6-meth...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed