BDBM50304202 CHEMBL604483::N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyphenyl]-6'-methoxy-7'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2c(Oc3ccc(cc3F)-c3nc4ccccc4s3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=RGGYJEYZTPRESN-UHFFFAOYSA-N

Data  7 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50304202   

LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataEC50:  780nMAssay Description:Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 190nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataEC50:  300nMAssay Description:Inhibition of TIE2 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 420nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 88nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304202(N-Methyl-N-[4-(benzo[d]thiazol-2''-yl)-3-methoxyph...)
Affinity DataIC50: 220nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed