BDBM50304197 CHEMBL593987::N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(-c4nc5ccccc5s4)c(F)c3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=ZUXFIRWLAQBCCS-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50304197   

TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 9nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataEC50:  2.60E+4nMAssay Description:Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 210nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 44nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304197(N-(4-(benzo[d]thiazol-2-yl)-3-fluorophenyl)-6-meth...)
Affinity DataIC50: 430nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed