BDBM50304174 4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]benzamide; oxalic acid::CHEMBL611933

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)c1ccc(Cl)cc1

InChI Key InChIKey=TXKIESIEWNDVGJ-UHFFFAOYSA-N

Data  3 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50304174   

TargetNociceptin receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50:  88nMAssay Description:Inverse agonist activity at NOP expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50:  6.80nMAssay Description:Activity at mu opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at delta opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at mu opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50:  42nMAssay Description:Activity at delta opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50:  7.10nMAssay Description:Activity at kappa opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at NOP expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304174(4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmeth...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed