BDBM50304172 17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-t-butyl)benzamido]morphinan-oxalate::CHEMBL611932

SMILES CC(C)(C)c1ccc(cc1)C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45

InChI Key InChIKey=COQVMBCVISUHKI-UHFFFAOYSA-N

Data  7 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50304172   

TargetNociceptin receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50:  15nMAssay Description:Inverse agonist activity at NOP expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50:  0.400nMAssay Description:Inverse agonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at mu opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at delta opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at kappa opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50:  4.00E+3nMAssay Description:Inverse agonist activity at mu opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50:  0.300nMAssay Description:Inverse agonist activity at delta opioid receptor expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at NOP expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi: >10nMAssay Description:Antagonist activity at delta opioid receptor expressed in HEK293 cells assessed as inhibition of compound 14-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at NOP expressed in HEK293 cells assessed as inhibition of compound 15-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at mu opioid receptor expressed in HEK293 cells assessed as inhibition of compound 11-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304172(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed