BDBM50303854 5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]imidazol-2-yl)furan-2-ylphosphonic acid::CHEMBL570790

SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12

InChI Key InChIKey=GSEADEUPRWQKIW-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50303854   

TargetFructose-1,6-bisphosphatase 1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of adenosine kinase AMP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AMP deaminase AMP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetATP-dependent 6-phosphofructokinase, muscle type(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of phosphofructokinase AMP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 550nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human liver FBPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed