BDBM50303750 2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL565996

SMILES COc1ccc(cc1Cl)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1

InChI Key InChIKey=NBTCNBCWVKBTIT-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303750   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataEC50:  190nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303750(2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3...)
Affinity DataIC50: 6.28E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed