BDBM50303746 2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL577905

SMILES COc1ccc(cc1)C1(N=C(N)N(C)C1=O)c1ccccc1

InChI Key InChIKey=VJOYOUKJSHACSN-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303746   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303746(2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-i...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303746(2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-i...)
Affinity DataEC50:  3.35E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303746(2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-i...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303746(2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-i...)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed