BDBM50303741 2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL566007

SMILES CN1C(N)=NC(C1=O)(c1ccccc1)c1ccc(Cl)cc1

InChI Key InChIKey=UKYITZHCXATSAD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303741   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303741(2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303741(2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataEC50:  2.13E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303741(2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303741(2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50: 3.82E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303741(2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-im...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed