BDBM50303587 1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea::CHEMBL568875

SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C

InChI Key InChIKey=RYCUVZMYBSSMAE-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50303587   

TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataIC50: 183nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataKd:  15nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataIC50: 440nMAssay Description:Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylurei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303587(1-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-ch...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylurei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed