BDBM50303503 CHEMBL4160782::US10858316, Compound SF-5-141

SMILES Cc1cc(Oc2ccc(cc2)S(=O)(=O)N2CC(Cc3ccccc23)C(O)=O)cc(C)c1Cl

InChI Key InChIKey=RGQCMYHCMAKVGY-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303503   

LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Inhibition of FITC-BAK binding to His6 tagged MBP fused recombinant human MCL1 (172 to 327 residues) expressed in Escherichia coli by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Inhibition of FITC-labelled BAK BH3 peptide to MCL-1 (172 to 327 residues) (unknown origin) assessed as inhibition constant by fluorescence polarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  286nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  5.01E+3nMAssay Description:Binding affinity to BCL-xL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed