BDBM50303229 6-(2,6-dichlorophenyl)-2-(4-(2,3-dihydroxypropylamino)phenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL567068

SMILES Cn1c2nc(Nc3ccc(NCC(O)CO)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=XCYATSRJUCZIJR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303229   

TargetMitogen-activated protein kinase 14(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303229(6-(2,6-dichlorophenyl)-2-(4-(2,3-dihydroxypropylam...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303229(6-(2,6-dichlorophenyl)-2-(4-(2,3-dihydroxypropylam...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303229(6-(2,6-dichlorophenyl)-2-(4-(2,3-dihydroxypropylam...)
Affinity DataIC50: 421nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303229(6-(2,6-dichlorophenyl)-2-(4-(2,3-dihydroxypropylam...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed