BDBM50303073 3-(6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL582808

SMILES Nc1nn2cccnc2c1-c1cc(ncn1)N1CCCC1c1ccc(F)cc1

InChI Key InChIKey=WNDJXHTVTVODGW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303073   

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303073(3-(6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidin-...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303073(3-(6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidin-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of JAK3 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303073(3-(6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidin-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human HT2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303073(3-(6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidin-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed