BDBM50303064 3-(6-(4-fluorobenzylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL570686

SMILES Nc1nn2cccnc2c1-c1cc(NCc2ccc(F)cc2)ncn1

InChI Key InChIKey=NDEINSMNUHKCPT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303064   

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303064(3-(6-(4-fluorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303064(3-(6-(4-fluorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK3 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303064(3-(6-(4-fluorobenzylamino)pyrimidin-4-yl)pyrazolo[...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed