BDBM50303035 4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)benzenesulfonamide::CHEMBL569998

SMILES Cc1ccc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1

InChI Key InChIKey=MTUNOSRERUFMFB-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303035   

TargetDickkopf-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303035(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataEC50:  7.80E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-casein signaling in osteosarcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303035(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandPNGBDBM50303035(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50: 19nMAssay Description:Inhibition of FLAG-tagged IKK-beta after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50303035(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of IKK-beta expressed in human HeLa cells transfected with pNFkappaB-luciferase assessed inhibition of TNF-alpha-induced NF-kappaB express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed