BDBM50302927 2-(N-tert-Butylamino)-3'-chloropentanophenone::2-(tert-butylamino)-1-(3-chlorophenyl)pentan-1-one::CHEMBL569465

SMILES CCCC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

InChI Key InChIKey=PREYWAJYVTVVPE-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50302927   

TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 370nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 472nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataKi:  96nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataKi:  1.17E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed