BDBM50302907 2-(N-Cyclopropylamino)-3-chloropropiophenone::CHEMBL569700

SMILES CC(NC1CC1)C(=O)c1cccc(Cl)c1

InChI Key InChIKey=YKOZIWZLLJVPPD-UHFFFAOYSA-N

Data  3 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50302907   

TargetSodium-dependent dopamine transporter(Rat)
Rti International

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataIC50: 533nMAssay Description:Inhibition of DAT-mediated dopamine uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Rti International

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of SERT-mediated serotonin uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Rti International

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataEC50:  1.33E+3nMAssay Description:Induction of SERT-mediated serotonin release in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataIC50: 265nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataKi:  3.42E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302907(2-(N-Cyclopropylamino)-3-chloropropiophenone | CHE...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed