BDBM50302902 CHEMBL566242::N-((6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-7-methoxy-1,5-naphthyridin-4-amine

SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc(F)c(F)c3)ccnc2c1

InChI Key InChIKey=PITVIIACVFAXRK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50302902   

TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302902(N-((6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-b]p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302902(N-((6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-b]p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302902(N-((6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-b]p...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302902(N-((6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-b]p...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed