BDBM50302897 (S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethoxy)quinoline::CHEMBL585293::US9066954, 164

SMILES COc1ccc2c(O[C@@H](C)c3nnc4ccc(nn34)-c3ccccc3)ccnc2c1

InChI Key InChIKey=FKNPFDGOZHGKTD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50302897   

TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50: 104nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50302897((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Affinity DataKi:  141nM ΔG°:  -9.40kcal/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
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