BDBM50302151 (S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazin-1-yl)pyridazin-3(2H)-one::CHEMBL572252

SMILES C[C@@H](COc1ccccc1Cl)n1nc(ccc1=O)N1CCNCC1

InChI Key InChIKey=CANDRMATFQVMGD-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50302151   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302151((S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazi...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302151((S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazi...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302151((S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazi...)
Affinity DataEC50:  506nMAssay Description:Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50302151((S)-2-(1-(2-chlorophenoxy)propan-2-yl)-6-(piperazi...)
Affinity DataKi:  728nMAssay Description:Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed