BDBM50302041 5-(5-((4-methoxypiperazin-1-yl)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile::CHEMBL570924

SMILES Cc1c(Nc2c(cncc2-c2cc3cc(CN4CC[N+](C)([O-])CC4)ccc3o2)C#N)ccc2[nH]ccc12

InChI Key InChIKey=KXRUTZLUYFIXDZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302041   

TargetProtein kinase C theta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302041(5-(5-((4-methoxypiperazin-1-yl)methyl)benzofuran-2...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human PKCtheta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302041(5-(5-((4-methoxypiperazin-1-yl)methyl)benzofuran-2...)
Affinity DataIC50: 110nMAssay Description:Inhibition of PKCdelta by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetProtein kinase C theta type(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302041(5-(5-((4-methoxypiperazin-1-yl)methyl)benzofuran-2...)
Affinity DataIC50: 360nMAssay Description:Inhibition of PKCtheta in C57BL/6 mouse T cells assessed as inhibition of anti-CD3 and anti-CD28-induced IL2 production after 20 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed