BDBM50301288 2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepine::CHEMBL568005

SMILES C(c1ccccc1)n1cc2CCNCCc2n1

InChI Key InChIKey=TVPVLONBSRPTBW-UHFFFAOYSA-N

Data  2 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50301288   

Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataEC50:  4.98E+3nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataEC50:  4.98E+3nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataEC50:  4.98E+3nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]-mesulergine from recombinant human 5-HT2C receptor transfected in Swiss mouse 3T3 cells after 150 mins by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301288(2-benzyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]-mesulergine from recombinant human 5-HT2C receptor transfected in Swiss mouse 3T3 cells after 150 mins by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed