BDBM50300912 (R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide::CHEMBL578197

SMILES CCS(=O)(=O)CCN([C@H](C)c1nc2ncccc2c(=O)n1-c1ccc(cc1)C#N)C(=O)Cc1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=VZIFJSRKHUPYAU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50300912   

TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 129nMAssay Description:Antagonistic activity to CXCR3 receptor expressed in PBMC assessed as inhibition of ITAC-mediated cell migration in presence of 100% human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMC in presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at CXCR3 assessed as inhibition of ITAC-mediated cell migration in presence of 100% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]-IP-10 from CXCR3 in presence of 100% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300912((R)-N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydropyrid...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-IP-10 from CXCR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed