BDBM50300903 CHEMBL570857::rac-N-(1-(3-(4-cyanophenyl)-8-(dimethylamino)imidazo[1,2-a]pyrazin-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

SMILES CCS(=O)(=O)CCN(C(C)c1nc2c(nccn2c1-c1ccc(cc1)C#N)N(C)C)C(=O)Cc1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=XZVSGHVDVWMTMY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300903   

TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300903(rac-N-(1-(3-(4-cyanophenyl)-8-(dimethylamino)imida...)
Affinity DataIC50: 27nMAssay Description:Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMC in presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300903(rac-N-(1-(3-(4-cyanophenyl)-8-(dimethylamino)imida...)
Affinity DataIC50: 45nMAssay Description:Antagonistic activity to CXCR3 receptor expressed in PBMC assessed as inhibition of ITAC-mediated cell migration in presence of 100% human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300903(rac-N-(1-(3-(4-cyanophenyl)-8-(dimethylamino)imida...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed