BDBM50300229 1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine::2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one::2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one::5,5-Diphenyl-2-iminohydantoin::CHEMBL291784

SMILES CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1

InChI Key InChIKey=RNWLAFWLSSMCLN-UHFFFAOYSA-N

Data  15 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50300229   

TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using Rh-EVNLDAEFK-quencher as substrate measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 770nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 770nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataEC50:  4.17E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRenin(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 770nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed