BDBM50300222 2-(4-{[(4-Chlorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid::CHEMBL572167

SMILES CCn1cc(C(O)=O)c(=O)c2cnc(nc12)N1CCN(CC1)C(=S)Nc1ccc(Cl)cc1

InChI Key InChIKey=NMACYVKZIUOPJV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50300222   

TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50300222(2-(4-{[(4-Chlorophenyl)amino]carbonothioyl}-1-pipe...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human autotaxin isolated from MDA-MB-231 cells assessed as blockade of FS3 substrate hydrolysis by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50300222(2-(4-{[(4-Chlorophenyl)amino]carbonothioyl}-1-pipe...)
Affinity DataKi:  5.70E+3nMAssay Description:Competitive inhibition of human autotaxin at free state isolated from MDA-MB-231 cells assessed as blockade of FS3 substrate hydrolysis by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed