BDBM50300205 7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H)-dione::CHEMBL571486

SMILES COc1cc2c3C(=O)NC(=O)c3cc(C)c2cc1OC

InChI Key InChIKey=DVMFNLSFJGRPMS-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300205   

TargetGlycogen synthase kinase-3 beta(Human)
Peking University

LigandPNGBDBM50300205(7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H...)
Affinity DataIC50: 1.01E+3nMpH: 7.4Assay Description:Briefly, recombinant human GSK3β (1 µM, 10 µL) was mixed with 10 µL of GSK3β substrate (YRRAAVPPSPSLSRHSSPHQpSEDEEE, 100 µM), 19 µL of 2.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Peking University

LigandPNGBDBM50300205(7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H...)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50300205(7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H...)
Affinity DataIC50: 787nMAssay Description:Inhibition of human CDK2/Cyclin A by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Peking University

LigandPNGBDBM50300205(7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H...)
Affinity DataKi:  259nMAssay Description:Inhibition of human recombinant GSK3-beta at 1 uM by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed