BDBM50299972 CHEMBL585164::Octanedioic Acid [4-(3-Azido-5-azidomethylbenzyloxy)phenyl]-amide Hydroxyamide

SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(OCc2cc(CN=[N+]=[N-])cc(c2)N=[N+]=[N-])cc1

InChI Key InChIKey=NAXINQWDISVTRE-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50299972   

TargetHistone deacetylase 8(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataIC50: 7.34E+3nMAssay Description:Inhibition of human recombinant HDAC8 using fluorescent acetylated substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of human recombinant HDAC3/NCoR2 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataIC50: 7.34E+3nMAssay Description:Inhibition of human recombinant HDAC8 using Fluor de Lys as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataIC50: 7.34E+3nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 25 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataKi:  740nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50299972(Octanedioic Acid [4-(3-Azido-5-azidomethylbenzylox...)
Affinity DataKi:  6.59E+3nMAssay Description:Inhibition of human recombinant HDAC8 using fluorescent acetylated substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed