BDBM50299864 CHEMBL574357::N-(1-(3-(5-Methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)cyclohexanamine::US8772508, 1

SMILES Cc1cncn1CCCN=C(C[N+]([O-])=O)NC1CCCCC1

InChI Key InChIKey=YAPJFJYUXSGRHO-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299864   

TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299864(US8772508, 1 | CHEMBL574357 | N-(1-(3-(5-Methyl-1H...)
Affinity DataKi:  44nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Probiodrug

US Patent
LigandPNGBDBM50299864(US8772508, 1 | CHEMBL574357 | N-(1-(3-(5-Methyl-1H...)
Affinity DataKi:  80nM IC50: 340nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent