BDBM50298837 (S)-5-(3-(2-methoxybiphenyl-4-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine::CHEMBL573306

SMILES COc1cc(ccc1-c1ccccc1)[C@H](C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=YYCPXVRHQUEVAW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298837   

TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298837(5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed