BDBM50298820 (R)-5-(3-(2-methoxy-2',6'-dimethylbiphenyl-4-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::CHEMBL574789

SMILES COc1cc(ccc1-c1c(C)cccc1C)[C@@H](C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=NUZPENCTXJLJCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298820   

TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298820((R)-5-(3-(2-methoxy-2',6'-dimethylbiphenyl-4-yl)bu...)
Affinity DataIC50: 32nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed