BDBM50298808 (+/-)-5-(3-(2,5-dimethoxyphenyl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::CHEMBL574329

SMILES COc1ccc(OC)c(c1)C(C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=SNSXAUHNYLILPV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50298808   

TargetDihydrofolate reductase(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298808((+/-)-5-(3-(2,5-dimethoxyphenyl)but-1-ynyl)-6-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298808((+/-)-5-(3-(2,5-dimethoxyphenyl)but-1-ynyl)-6-meth...)
Affinity DataIC50: 48nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed