BDBM50298799 (+/-)-5-(3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)prop-1-ynyl)-6-methylpyrimidine-2,4-diamine::CHEMBL572717

SMILES COc1cc(CC#Cc2c(C)nc(N)nc2N)cc(c1)-c1c(C)cccc1C

InChI Key InChIKey=ZPKUFQIPDAOKAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50298799   

TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298799((+/-)-5-(3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298799((+/-)-5-(3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed