BDBM50297955 3-{[5-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-1H-indol-1-yl]sulfonyl}benzoic acid::CHEMBL549310

SMILES CC(C)c1onc(c1COc1ccc2n(ccc2c1)S(=O)(=O)c1cccc(c1)C(O)=O)-c1c(Cl)cccc1Cl

InChI Key InChIKey=FLCYQOXMJYAMLK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297955   

TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297955(3-{[5-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-...)
Affinity DataEC50:  160nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297955(3-{[5-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-...)
Affinity DataEC50:  1.30E+3nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed