BDBM50297954 3-{[5-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-1H-indol-3-yl]methyl}benzoic acid::3-{[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-1H-indol-3-yl]methyl}benzoic acid::CHEMBL552352

SMILES CC(C)c1onc(c1COc1ccc2c(Cc3cccc(c3)C(O)=O)c[nH]c2c1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=PUMKNVRDHABPBG-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297954   

TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297954(3-{[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-...)
Affinity DataEC50:  590nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297954(3-{[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-...)
Affinity DataEC50:  930nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed